Toxicology & Conjugates, New Modalities & Unfamiliar Compounds: Working with Interdisciplinary Teams
- Early engagement between toxicology and R&D teams is becoming essential as advanced therapeutics like trispecific mAbs, ADCs, and radio conjugates become more prevalent, ensuring safety considerations are embedded from the start
- Streamlining toxicological assessment in a fast-evolving therapeutic landscape when a compound is both biological and a high potency small molecule: Are industrial hygiene and toxicology teams working together?
- Cross-functional collaboration between industrial hygiene and toxicology is critical to efficiently assess the risks of complex compounds that combine biological and high-potency characteristics
- Moving beyond default worst-case assumptions enables smarter innovation, with more nuanced, evidence-based toxicity assessments that balance safety with scientific progress